MiRNA-433 and Cancers
Jie Tang1, Desheng Ni2, Song Li21Department of General Surgery, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, China, 2Department of Hepatobilary Pancreatic Gastrointestinal Surgery, JinHua People's Hospital, JinHua, Jinhua, China,
Being a carrier of genes encoding post-transcriptional regulatory information, miRNA-433 has a crucial regulatory role in cell growth and development in animals and plants. We found that miRNA-433 is associated with 19 cancers, with its expression significantly downregulated in 17 cancers. MiRNA-433 overexpression can inhibit the proliferation, mi gration, and invasion of cancer cells. These include cells of cholangiocarcinoma, liver cancer, pancreatic cancer, breast cancer, etc. MiRNA-433 suppresses the expression of this target gene by binding to the specific seed sequence of the downstream target gene Notably, the seed sequences of different downstream target genes that miRNA-433 binds to are the same. In this article, we discuss in detail the mechanism of miRNA-433 in human diseases and provide ideas for further research on its biological functions. Keywords: Cancer, Human diseases, MiRNAs, MiRNA-433
Cite This Article
Tang J, Ni D, Li S. MiRNA-433 and Cancers. EJMO. 2023; 7(4): 289-297
Corresponding Author: Song Li