About a third of the global population suffers from non-alcoholic fatty liver disease (NAFLD). The disease develops with no specific signs along with other co-morbidities. Both genetic polymorphisms and external risk factors are correlated with the disease. NAFLD is characterized by the accumulation of fat within hepatocytes that precede its progression to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma/hepatic failure. The standard management involves compliance with a fat and sugar-poor diet as well as other lifestyle alterations. Nonetheless, recent studies have shown that some foods and nutraceuticals exhibited beneficial effects toward NAFLD. This paper offers a short review of the pathophysiology, risk factors, and nutritional detoxification of NAFLD. Keywords: NAFLD, free fatty acids, metabolic syndrome, detoxification, xenobiotics, synbiotics.
Corresponding Author: Haitham Ahmed Al-Madhagi