The Effect of Vitamin D Deficiency on Platelet Indices in Various Anemia Groups
Aziz Sener1, Semra Isikoglu Hatil1, Abdullah Uner2, Rabia Seker1, Ilknur Alkan Kusabbi1, Arzu Kosem11Department of Clinical Biochemistry, Ankara Etlik City Hospital, Türkiye, 2Department of Clinical Biochemistry, Ordu University Training and Research Hospital, Türkiye,
Objectives: Our study aimed to determine the effects of vitamin D deficiency in iron, folate (B9), and cobalamin (B12) deficient anemia patients and their platelet indices. Methods: The study included 4000 patients who presented to the outpatient clinics of Ankara Etlik City Hospital between September 9, 2022, and May 1, 2023. Four groups were studied: patients with iron deficiency anemia, B9 deficiency anemia, B12 deficiency anemia, and a control group without anemia. These four groups were subdivided according to 25 (OH) vitamin D levels as patients with and without vitamin D deficiency. Each subgroup contained 500 patients. We compared mean platelet volume (MPV), platelet distribution width (PDW), platelet count (PLT), and platelet-large cell ratio (P-LCR) parameters between the groups according to the anemia and control groups’ vitamin D levels. In addition, univariate linear regression analysis and multivariate linear regression analysis were performed to determine the factors affecting these parameters. Results: We detected that the presence of vitamin D deficiency together with B12 deficiency anemia affected MPV values (p<0.01). We also detected that the presence of vitamin D deficiency together with iron deficiency anemia af fected P-LCR (p<0.01). Conclusion: Vitamin D deficiency increased the severity of platelet morphology deterioration in patients with B12 and iron deficiency anemia compared with patients with normal vitamin D levels. Patients with B12 and iron deficiency anemia should also be screened for vitamin D deficiency to prevent changes in platelet morphology. Therefore, com plications associated with deterioration in platelet morphology and function in anemia patients might be prevented by vitamin D supplementation. Keywords: Anemia, platelet, vitamin D, mean platelet volume, platelet distribution width, platelet- large cell ratio
Cite This Article
Sener A, Hatil S, Uner A, Seker R, Kusabbi I, Kosem A. The Effect of Vitamin D Deficiency on Platelet Indices in Various Anemia Groups. EJMO. 2024; 8(2): 199-206
Corresponding Author: Aziz Sener