Could Higher Platelet Indices on Admission Predict Re-Infarction & Adverse Outcomes in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention (PPCI)? A Single-Center Experience
Alaa Eldin Abd Elmoniem1, Ahmad F Thabet1, Ishraq Hosny Abd El-Hameed,1, Mohamed Aboel- Kassem F Abdelmegid2, Aml Adel Rayan3, Sawsan M Moeen11Department of Internal Medicine, Critical Care Unit and Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt, 2Cardiovascular Medicine Department, Assiut University Heart Hospital, Assiut University, Assiut, Egypt, 3Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt,
Objectives: Platelet indices, such as platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), can provide insights into platelet activation. Large platelets are more active and have higher thrombotic poten tial than small platelets, suggesting that larger platelets play a role in ST-elevation myocardial infarction (STEMI). To assess PDW, MPV, and PCT and their relation to severity and validity for prediction of primary, secondary outcomes, and MACE in acute STEMI patients who underwent PPCI. Methods: This prospective study included 115 consecutive STEMI patients who underwent PPCI. Admission blood samples were measured for MPV, PDW, and PCT. The SYNTAX and Gensini (GS) scores were used to quantify the severity of CAD. Patients were followed up for a period of 3 to 6 months with regard to primary and secondary clinical outcomes. Results: PDW had a moderate positive correlation with SYNTAX score (r=0.321, p<0.001) and GS (r=0.270, p=0.002), and a negative correlation with TIMI Risk (r=-0.199, p=0.017) and ejection fraction (r=-0.170, p=0.034). Also, MPV had a significant positive correlation with SYNTAX score (r=0.235, p=0.006). PDW had the highest diagnostic accuracy for the prediction of the primary outcome and MACE. Conclusion: PDW, a low-cost and easily measured laboratory test, could be used as a predictor of re-infarction and adverse outcomes in STEMI patients. Keywords: Mean platelet volume, Platelet distribution width, plateletcrit, primary percutaneous coronary interven tion, ST-elevation myocardial infarction
Cite This Article
Elmoniem A, Thabet A, El-Hameed, I, Abdelmegid M, Rayan A, Moeen S. Could Higher Platelet Indices on Admission Predict Re-Infarction & Adverse Outcomes in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention (PPCI)? A Single-Center Experience. EJMO. 2024; 8(3): 311-321
Corresponding Author: Sawsan M Moeen