Ki-67 Expression, Mast Cells Positive to Tryptase, and Angiogenesis in Gastric Cancer Patients Undergoing Radical Surgery
Michele Ammendola1, Francesca Vescio1, Giorgio Ammerata2, Maria Luposella3, Rosa Patruno4, Carmelo Laface5, Valeria Zuccala61Department Health of Science, Digestive Surgery Unit, University “Magna Graecia” Medical School, Viale Europa, Germaneto, Catanzaro, Italy, 2Department Health of Science, General Surgery Unit, University “Magna Graecia” Medical School, Viale Europa, Germaneto, Catanzaro, Italy Department Health of Science, General Surgery Unit, University “Magna Graecia” Medical School, Viale Europa, Germaneto, Catanzaro, 3Cardiovascular Disease Unit, General Hospital of Soverato, Catanzaro, Itlay, 4Chair of Pathology, Veterinary Medical School, University “Aldo Moro” of Bari, Via Casamassima, Bari, Italy, 5Interventional Oncology Unit with Integrated Section of Translational Medical Oncology National Cancer Research Centre, Istituto Tumori “Giovanni Paolo II”, viale Orazio Flacco 65, Bari, Italy, 6Pathology Unit, “Pugliese-Ciaccio” Hospital, Viale Pio X°, Catanzaro, Italy Pathology Unit, “Pugliese-Ciaccio” Hospital, Viale Pio X°, Catanzaro, Italy,
Objectives: Tumor proliferation is guided by neoangiogenesis; microvascular density (MVD) in the tumor micro-environment increases with the action of different immune system stromal cells such as the mast cells (MCs). Methods: We evaluated Ki-67 proliferation rate, MCs positive to tryptase (MCPT), and MVD in a series of 85 gastric cancer (GC) tissue samples from patients undergoing radical surgery. Results: In tumor tissue, a significant correlation between Ki-67 expression, MCPT, and MVD was found through Pearson t-test analysis (p ranged from 0.01 to 0.03). Conclusion: Ki-67 expression and MVD may indicate the survival prognosis of patients and MCPT could repre-sent a biological marker of radical surgery and angiogenesis. Furthermore, MCPT could be consid-ered as a target of novel anti-angiogenic therapies in GC patients. Keywords: Angiogenesis, gastric cancer, mast cells, surgical oncology, tumor microenvironment, tumor pro-liferation
Cite This Article
Ammendola M, Vescio F, Ammerata G, Luposella M, Patruno R, Laface C, et al. Ki-67 Expression, Mast Cells Positive to Tryptase, and Angiogenesis in Gastric Cancer Patients Undergoing Radical Surgery. EJMO. 2023; 7(1): 62-69
Corresponding Author: Michele Ammendola