Objectives: This study mainly analyzes the association between serum interleukin-6(IL-6) and interleukin-8(IL-8) levels and clinical benefit from immune checkpoint inhibitors in patients with advanced gastric cancer. Methods: The clinical characteristics of 51 patients with advanced gastric cancer, diagnosed in our hospital and treated with immune checkpoint inhibitors, were analyzed retrospectively in our study. Results: After three cycles of immunotherapy, the level of serum IL-6 decreased in 10 patients (37%) and the level of serum IL-8 decreased in 27 patients (52%). Compared with patients with increased serum IL-6 level, patients with decreased serum IL-6 level tended to have higher partial response (PR), stable disease (SD), but the difference was not statistically significant. Compared with patients with increased serum IL-8 level, there were significant differences in PR, SD for patients with decreased serum IL-8 level(P?0.05). Patients with decreased serum IL-6 or IL-8 levels tended to have better progression-free survival(PFS) and overall survival(OS) than those with increased serum IL-6 or IL-8 levels. Conclusion: The changes in IL-6 and IL-8 levels could be as predictive indicators to predict benefit from immune checkpoint inhibition in advanced gastric cancer. Patients with decreased serum IL-6 or IL-8 levels during immunotherapy may achieve better clinical benefit. Keywords: Gastric cancer, interleukin-6, interleukin-8, immune checkpoint inhibitor
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