Ahead of Print | DOI: 10.14744/ejmo.2023.33713

Linked Color Imaging Color Analytic Model Based on Pixel Brightness for Diagnosing H. Pylori Infection in Gastric Antrum

Xiaotian Sun¹, Cuiyun Ma², Xueting Zhang³, Chang Lu³, Haiyan Yu², Wei Zhang¹, Ying Wang³, Yang Xu^2
1Department of Internal Medicine, Southern Medical Branch of PLA General Hospital, Beijing, China, ²Department of Gastroenterology, the Fifth Medical Center of PLA General Hospital, Beijing, China, ³Clinic of Fuxing Road, Southern Medical Branch of PLA General Hospital, Beijing, China.,

Objectives: Linked color imaging (LCI) helps to differentiate minor mucosal changes, which can be objectively judged by red-green-blue (RGB) pixel brightness. However, whether this color analytic model based on pixel brightness can be applied to diagnose H. pylori infection remains unknown. Methods: Consecutive adult patients with indications and underwent esophagogastroduodenoscopy for the first time were enrolled in the training (n=166) and validation (n=79) set. Demographic and clinical characteristics were recorded. Target region in gastric antrum was pictured before biopsy for rapid urea test, and pixel brightness was calculated by Matlab software. Results: In training set, 25 patients had H. pylori infection. Pixel brightness for R and B in patients with H. pylori infection were greatly higher than those in patients without H. pylori infection (R 210.203 ± 27.233 vs. 196.401 ± 29.018, P=0.043; B 127.621 ± 26.112 vs. 125.334 ± 27.812, P=0.025). At the cut-off of R = 210 and B = 127, the specificity and sensitivity was 0.696 and 0.701. In validation set, 10 patients had H. pylori infection and the findings were consistent with those in training set. Conclusion: Color analytic model based on pixel brightness under LCI was useful in diagnosing H. pylori infection in gastric antrum. Keywords: H. pylori infection; esophagogastroduodenoscopy; linked color imaging; diagnostic efficacy; pixel brightness value.

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Cite This Article

Sun X, Ma C, Zhang X, Lu C, Yu H, Zhang W, et al. Linked Color Imaging Color Analytic Model Based on Pixel Brightness for Diagnosing H. Pylori Infection in Gastric Antrum. EJMO. ; (): -

Corresponding Author: Yang Xu