Role of lncRNA Alterations in Cervical Oncogenesis
Alan Lopes de Oliveira1, Valéria Duarte de Almeida2, Tauê Posada Pereira2, Amanda Estevam Carvalho2, Victor Sena Nogueira Wojcieszyn2, Micássio F. Andrade21Department of Biomedical Sciences, School of Health Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte, Brazil Department of Biomedical Sciences, School of Health Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte, Brazil, 2Department of Biomedical Sciences, School of Health Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte, Brazil,
Objectives: Human Papillomavirus (HPV) is the main contributor to the development of cervical cancer. This study aimed to investigate the biological significance of changes in the expression of lncRNAs induced by HPV oncoproteins in cervical oncogenesis mechanisms. Methods: We performed a review using online databases. The alterations were associated with some molecular and/or cellular characteristics that could be involved in the pathogenesis of cervical cancer. The molecular targets of the RNAs were identified using the Gene Expression Profiling Interactive Analysis (GEPIA) bioinformatics sites/tools, GeneCards®, OMIM, and Lnc2Cancer 3.0. Results: Sixty-one altered lncRNAs were identified. The alterations contribute to the higher staging of cervical cancer and a worse prognosis. These lncRNAs can act by competing for miRNAs for response elements, influencing the regulation of target genes and, ultimately, participating in the cancer regulation process and exhibit multiple biological functions, such as chromatin modification, transcription, translation, splicing, and epigenetic regulation. Conclusion: Changes in lncRNA expression have been associated with the onset, progression, and prognosis of cervical cancer. These changes can contribute to several features of cervical oncogenesis, and their identification has the potential to provide new biomarkers and therapeutic targets for the treatment of this cancer. Keywords: Cervical cancer, HPV Human Papillomavirus, Long Noncoding, Oncogenesis, RNA
Cite This Article
Oliveira A, Almeida V, Pereira T, Carvalho A, Nogueira Wojcieszyn V, Andrade M. Role of lncRNA Alterations in Cervical Oncogenesis. EJMO. 2022; 6(2): 111-120
Corresponding Author: Valéria Duarte de Almeida