Predictive Factors for Surgery in Preterm Neonates with Necrotizing Enterocolitis: A Retrospective Cohort Study
Mohamed Zouari1, Hana Ben Ameur2, Nesrine Ben Saad1, Najoua Kraiem1, Oussama Ghariani3, Amel Ben Hamad4, Riadh Mhiri11Faculty of medicine of Sfax, University of Sfax, Sfax, Tunisia, 2Department of pediatric surgery, Hedi Chaker Hospital, Sfax, Tunisia, 3Department of neonatology, Hedi Chaker Hospital, Sfax, Tunisia Department of neonatology, Hedi Chaker Hospital, Sfax, Tunisia, 4Department of neonatology, Hedi Chaker Hospital, Sfax, Tunisia,
Objectives: Necrotizing enterocolitis (NEC) is a severe neonatal condition. This study aimed to assess predictive factors for surgical treatment in preterm neonates with NEC in a Tunisian center. Methods: We present a retrospective study including all neonates treated for NEC between January 01, 2010 and March 31, 2022. Results: Within the study period, 102 patients were included, with an overall survival of 47%. Most of our patients were male (64.7%), with low birth weight or less (100%), 5-min Apgar score ?8 (79.4%), and Bell’s stage II (66.7%). Multivariate logistic analyses demonstrated that gestational age <30 weeks (p=0.002, odds ratio [OR]=4.544), birth weight <1000 g (p=0.001, OR=5.750), NEC onset <7 days (p<0.001, OR=5.667), not being breastfed (p=0.019, OR=3.026), and C-reactive protein level >20 mg/L (p=0.020, OR=2.942) were associated with the need for surgical treatment in neonates with NEC. Conclusion: Our findings would be helpful in refining treatment modalities for better disease outcomes. Keywords: Bell's staging criteria, breastfeeding, C-reactive protein, Necrotizing enterocolitis, surgery
Cite This Article
Zouari M, Ameur H, Saad N, Kraiem N, Ghariani O, Hamad A, et al. Predictive Factors for Surgery in Preterm Neonates with Necrotizing Enterocolitis: A Retrospective Cohort Study. EJMO. 2022; 6(4): 358-363
Corresponding Author: Mohamed Zouari