The Incidence of Composite Lymphomas: Case Studies And disease Management
Svetlana Smirnova1, Tatiana Moiseeva2, Lubov Al-Radi2, Yulia Sidorova1, Elena Nikulina1, Lubov Plastinina2, Andrey Sudarikov31National Research Center for Hematology, Laboratory of Molecular Hematology, 4 Noviy Zykovskiy Proezd, Moscow, Russia, 2National Research Center for Hematology, Consultative Hematology Department with a Day-Care Hospital, 4 Noviy Zykovskiy Proezd, Moscow, Russia, 3National Research Center for Hematology, Department of Pathology, 4 Noviy Zykovskiy Proezd, Moscow, Russia,
Objectives: Composite lymphomas (CL), which are a combination of different types of lymphomas in a single patient can occur simultaneously or sequentially. Diagnosis and treatment of CL require a full range of modern approaches. Methods: The study included 37 cases of CL (M:F=2:1), the median age of patients was 64 (38-83 years). All patients underwent a full range of diagnostic procedures, including histopathological, immunohistochemical/immunophenotypic (flow cytometry), cytogenetic/FISH, and molecular tests at the National Research Centre for Hematology, Moscow. Results: Metachronous CL were observed in 17 cases and the most common type of the second lymphoma was diffuse large B-cell lymphoma (DLBCL) or Hodgkin's lymphoma (HL). In 30% of cases, DLBCL developed after HL therapy, and in 30% - after therapy of angioimmunoblastic T-cell lymphoma (AITL). In 20 cases of synchronous CL the most common was B-cell chronic lymphocytic leukemia (B-CLL) combined with hairy cell leukemia (HCL) - 54.5%, large granular lymphocytic leukemia, marginal zone lymphoma (MZL), follicular lymphoma, multiple myeloma, or mycosis fungoides. A combination of HL with other lymphoma was observed in 25% of cases (HL+MZL represent 60% of cases). Conclusion: CL are excellent models for studying the complex process of tumor cells evolution during the course of the disease. Treatment of CL is a non-trivial task and aims to control both diseases. Keywords: Composite lymphomas
Cite This Article
Smirnova S, Moiseeva T, Al-Radi L, Sidorova Y, Nikulina E, Plastinina L, et al. The Incidence of Composite Lymphomas: Case Studies And disease Management. EJMO. 2022; 6(2): 130-136
Corresponding Author: Andrey Sudarikov