P-ISSN 2587-2400 | E-ISSN 2587-196X
EJMO Volume : 4 Issue : 3 Year : 2020
EJMO. 2020; 4(1): 79-83 | DOI: 10.14744/ejmo.2020.52684

The Outcome of Autologous Stem Cell Transplantation in Adolescent and Young Adult Patients with Multiple Myeloma

Tugce Nur Yigenoglu1, Semih Basci1, Bahar Uncu Ulu1, Mehmet Bakirtas1, Derya Sahin1, Tahir Darcin1, Jale Yildiz1, Alparslan Merdin1, Nuran Ahu Baysal1, Dicle Iskender1, Merih Kizil Cakar1, Mehmet Sinan Dal1, Fevzi Altuntas1
1Department of Hematology and Bone Marrow Transplantation Center, University of Health Sciences, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey

Objectives: Multiple myeloma (MM) is a disease of the elderly and peaks at 60-to-70 years of age. The disease is rarely observed in young age groups. The incidence of MM is 2% among the patients under 40 years of age. Methods: In this retrospective study, we analyzed the results of MM patients in the adolescents and young adults (AYA) age group who were treated in our center between January 2010 and July 2018. Results: Of the 212 MM patients, 7% (15/212) were in the AYA age group. The median progression-free survival (PFS) was 20.3 months, and the median overall survival (OS) was 41.5 months among patients in the AYA age group. In the group of patients who were over 40 years of age, the median PFS was 19.07 months, and the median OS was 30.1 months. At the time of diagnosis, the patients in the group that was 40 years of age or older were, more frequently International Staging System (ISS) 2 and ISS 3, while patients in the AYA group were more often ISS 1. Conclusion: As the goal is to achieve longer OS, and the incidence of comorbidities in younger patients is low, augmented treatments should be considered. Keywords: Autologous hematopoietic stem cell transplantation, adolescent young adult, multiple myeloma

Cite This Article

Yigenoglu T, Basci S, Uncu Ulu B, Bakirtas M, Sahin D, Darcin T, Yildiz J, Merdin A, Baysal N, Iskender D, Kizil Cakar M, Dal M, Altuntas F. The Outcome of Autologous Stem Cell Transplantation in Adolescent and Young Adult Patients with Multiple Myeloma. EJMO. 2020; 4(1): 79-83

Corresponding Author: Semih Basci

Full Text PDF PDF Download