P-ISSN 2587-2400 | E-ISSN 2587-196X
EJMO Volume : 4 Issue : 3 Year : 2020
EJMO. 2020; 4(3): 209-214 | DOI: 10.14744/ejmo.2020.44446

Immunotherapy in Geriatric Patients With Advanced Cancer

Birol Yildiz1, Ramazan Acar2
1Department of Medical Oncology, Elazig Fethi Sekin City Hospital, Elazig, Turkey, 2Department of Medical Oncology, Health Sciences University, Gulhane Training and Research Hospital, Istanbul, Turkey

Objectives: Successful responses have been obtained in treating many solid and hematological cancers using PD-1 and PDL-1 inhibitors as immunotherapy treatments. Although cancer appears more frequently in elderly patients, this group is not usually included in clinical trials. Therefore, studies involving geriatric patients cannot reflect real-life data. The aim of our study is to share the real-life data of patients aged 65 and over who had different cancer diagnoses and received immunotherapy treatments. Methods: In our study, patients aged ?65 years who received immunotherapy treatment at our center between 16.02.2016 and 31.12.2019 were evaluated retrospectively. The primary outcome was treatment tolerance and progression- free survival (PFS). The secondary outcomes was overall survey immunotherapy (OSim). Results: The median age of starting immunotherapy was 70 years (range 66–78). Comorbid diseases were present in 20 (74%) of the patients. The most common primary malignancy type was renal cell cancer (RCC) (n=9, 33.3%). The median PFS was 7.3 (range 1–49) months. After immunotherapy, complete response (CR) was seen in 2 (7.4%) patients, partial response (PR) in 13 (48.1%), stable response in 5 (18.5%), and progression in 7 (25.9%). The most common side effect was fatigue, occurring in 44.4% (n=12) of patients. Moreover, 66.7% (n=18) experienced an immunotherapy-related adverse event (irAE), among which rash (21%), thyroid dysfunction (13%), and pneumonitis (12%) were the most common. No patient was dead due to treatment-related side effects. Conclusion: Although the efficacy of immunotherapy treatments was affected by comorbid diseases among cancer patients, it was observed that the elderly patients have

Cite This Article

Yildiz B, Acar R. Immunotherapy in Geriatric Patients With Advanced Cancer. EJMO. 2020; 4(3): 209-214

Corresponding Author: Birol Yildiz

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