P-ISSN 2587-2400 | E-ISSN 2587-196X
Ahead of Print | DOI: 10.14744/ejmo.2019.94710

Ethnic differences in Hematologic toxicity from Imatinib in patients with Gastrointestinal Stromal cell tumor (GIST)

Muhammad Wasif Saif1, Sneha Purvey1, Krsitin Kaley1, Nawal Wasif1, Annmarie Carmel1, Teresa Rodriguez1, Kenneth B Miller1
1Northwell Health - Northwell Health Cancer Institute 450 Lakeville Road , Lake Success, New York 11042 United States

Objective: There is a wide variability in the pharmacokinetics, pharmacodynamics and tolerance of anticancer drugs based on ethnicity. GIST is a rare cancer, (~1% of GI cancers). Imatinib is used in the neo-adjuvant, adjuvant and metastatic setting. Methods: The purpose of this study was to report the difference in hematologic toxicities to imatinib among different ethnicities when treated for GIST either in the adjuvant or metastatic setting. Results: Among 57 patients (median age 61 years, M:F = 41:16(F); ethnicities: White 65%, African-American (AA 19%, Asian 12% and Hispanic 3%), neutropenia (Grade 3 & 4) was seen in 6 patients (10%): 5 AA and 1 Asian. 45% of all AA patients developed neutropenia. Median absolute neutrophil count (ANC) nadir was 700/µL, median duration on drug prior to onset of neutropenia was 4.5 weeks and median duration of neutropenia was 4 weeks. One patient developed febrile neutropenia. Dose interruptions were needed in 3, dose-reductions in all patients, and 3 patients required pegfilgrastim. One patient had to discontinue imatinib, while one patient was escalated back to 400mg daily dose. Conclusions: This is the first study to examine ethnic variations in myelosuppression following imatinib in patients with GIST. Keywords: Gastrointestinal stromal tumors, imatinib, ethnicity, neutropenia, anemia


Cite This Article

Saif M, Purvey S, Kaley K, Wasif N, Carmel A, Rodriguez T, Miller K. Ethnic differences in Hematologic toxicity from Imatinib in patients with Gastrointestinal Stromal cell tumor (GIST). EJMO. ; (): -

Corresponding Author: Saif M.

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