P-ISSN 2587-2400 | E-ISSN 2587-196X
EJMO. 2019; 3(4): 263-268 | DOI: 10.14744/ejmo.2019.72964

P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia

Seyed Amir Tabatabaei1, Mohammad Ali Jalali Far1, Ali Amin Asnafi1, Farzaneh Tavakoli2, Zari Tahannejad Asadi3
1Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, 2Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3Department of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Objectives: Acute lymphoblastic leukemia (ALL) occurs due to the defective maturation of lymphoid cells and lack of differentiation. The present study was aimed to determine the prevalence of P190 BCR-ABL1 transcript in ALL patient and their relation with age, gender, and ethnicity in Iranian population. Methods: This cross-sectional research was done on 50 children with ALL including 28 (56%) males and 22 (44%) females. The presence of P190 BCR-ABL1 transcript was assessed by Nested-PCR technique. Results: From 50 ALL patients, P190 BCR-ABL1 transcript with e1-a2 fusion gene was positive in 2 (4%) cases, one patient (50%) male, and one female (50%) with <5 years old age range and Arab ethnicity. Conclusion: It seems that P190 BCR-ABL1 transcript prevalence and its relations with diagnosis and prognosis, age and ethnicity of ALL patients, need a higher population of the patients to better achievement in this field. Keywords: Acute lymphocytic leukemia, BCR-ABL1, Nested-PCR


Cite This Article

Tabatabaei S, Jalali Far M, Asnafi A, Tavakoli F, Asadi Z. P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia. EJMO. 2019; 3(4): 263-268

Corresponding Author: Asadi Z.

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