EJMO. 2019; 3(4): 263-268 | DOI: 10.14744/ejmo.2019.72964

P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia

Seyed Amir Tabatabaei¹, Mohammad Ali Jalali Far¹, Ali Amin Asnafi¹, Farzaneh Tavakoli², Zari Tahannejad Asadi^3
1Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, ²Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, ³Department of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

Objectives: Acute lymphoblastic leukemia (ALL) occurs due to the defective maturation of lymphoid cells and lack of differentiation. The present study was aimed to determine the prevalence of P190 BCR-ABL1 transcript in ALL patient and their relation with age, gender, and ethnicity in Iranian population. Methods: This cross-sectional research was done on 50 children with ALL including 28 (56%) males and 22 (44%) females. The presence of P190 BCR-ABL1 transcript was assessed by Nested-PCR technique. Results: From 50 ALL patients, P190 BCR-ABL1 transcript with e1-a2 fusion gene was positive in 2 (4%) cases, one patient (50%) male, and one female (50%) with <5 years old age range and Arab ethnicity. Conclusion: It seems that P190 BCR-ABL1 transcript prevalence and its relations with diagnosis and prognosis, age and ethnicity of ALL patients, need a higher population of the patients to better achievement in this field. Keywords: Acute lymphocytic leukemia, BCR-ABL1, Nested-PCR

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Cite This Article

Tabatabaei S, Jalali Far M, Asnafi A, Tavakoli F, Asadi Z. P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia. EJMO. 2019; 3(4): 263-268

Corresponding Author: Zari Tahannejad Asadi

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