Transient receptor potential vanilloid 1 channels (TRPV1) which are playing an important role in conduction of pain signals to dorsal root ganglion (DRG), can be interacted by many external and internal factors. Food ingredients and herbal products have a great impact on these receptors. Topical application or oral consumption of these products are effective in reducing pain signals with different mechanisms of action. TRPV1 is involved in a various processes including nociception, thermosensation and energy homeostasis. Role of capsaicin, unsaturated omega fatty acids, minerals, and herbal products in pain relief and molecular mechanisms are being discussed. However, some dietary supplementation with TRPV1 activity, such as capsaicin, show conflicting results. TRPV1 channels and their agonist elements may play a great impact in decreasing the risk of obesity and diabetes through different mechanisms including reducing inflammation. Therefore, TRPV1 could be dysregulated in obesity leading to the development of obesity, diabetes. Further, TRPV1 channels look like to be responsible in pancreatic insulin secretion. Hopefully, we could make it possible to produce natural food supplements to reduce pain by focusing on the role of TRPV1 channels. This will further help clinicians and surgeons to reduce pain post-surgical procedures just by modifying the patientís diet. Keywords: Capsaicin, diet, pain, trpv1
Corresponding Author: Farzamirad V.