Objectives: Neutrophile-lymphocyte ratio (NLR) is an inflammatory marker and has prognostic significance for many cancers.In this study, we evaluated the prognostic value of NLR ratio and its relation with clinicopathological features in gastric cancer. Methods: A retrospective review of 110 patients who underwent stomach cancer surgery between 2012 and 2014 was performed electronically. Results: The mean age was 63.7±11.6 years.Seventy percent of the patients were male and 43% underwent total and 57% subtotal gastrectomies. According to TNM staging; 11% were in stage 1, 29% in stage 2 and 60% in stage 3. Metastatic/ total lymph node ratio is below 0.3 in 59% of patients. Neutrophil/lymphocyte ratio was found to be greater than 2.5 in 50% of patients and greater than 3 in 33% of patients. The mean NLR value was 3.38±2.7 (1.09-19.1). Conclusion: In our study, while NLR was not detected as an effective factor on disease-free survival; stage, metastatic lymph node ratio, tumor size and localization were found as independent factors effective on overall survival. As a significant factor in multivariate analysis, NLR reflects the immune status of the organism, not the tumor aggressiveness or stage and it is an independent prognostic factor. Keywords: Disease free survival (DFS), gastric cancer, neutrophile lymphocyte ratio (NLR), overall survival (OS)
Corresponding Author: Ustuner M.