Objectives: In this study, we aimed to undertake a systematic review of the literature in order to investigate whether preoperative biomarkers have diagnostic significance in determining post-implantation syndrome PIS possibility after endovascular aneurysm repair (EVAR). Methods: Literature review was carried out in PubMed electronic database without any limitations of date. Included were studies that recorded the preoperative levels of inflammatory biomarkers in which PIS develops following EVAR and that were published only in English. Results of the studies were evaluated based on either random or fixed effect model in accordance with the presence of heterogeneity (I2>25%). Statistical analysis were performed by Open meta Analyst® software. Results: A total of 349 articles were found upon a database screening. After the article titles and abstracts were analysed, 6 articles were included in the meta-analysis that cover 891 patients and comply with inclusion criteria. It was observed in the studies that WBC, CRP, thrombocyte, IL-6, and fibrinogen levels were analysed. It was found from the conducted analysis that the preoperative levels of WBC (SMD: 0.70 95% CI: 0.55-0.86 and p<0.001), fibrinogen (SMD: 0.27 95% CI: 0.03-0.51 and p=0.02), IL-6 (SMD: 1.04 95% CI: 0.64-1.44 and p<0.001), and thrombocyte (SMD: 0.91 95% CI: 0.13-0.69 and p=0.02) were significant in determining the PIS development, however, CRP levels were not (SMD: 0.37 95% CI: -0.20-0.96 and p=0.20). Conclusion: We concluded that WBC, thrombocyte, fibrinogen, and IL-6 levels were effective in predicting PIS developing after EVAR in preoperative period. Keywords: Biomarker, endovascular aneurysm repair, meta-analysis, post-implantation syndrome
Corresponding Author: Ozturk S.