Histologic Grade with Thyroid Transcription Factor 1 and Sample Type Serve as Independent Factors for the Incidence of EGFR Mutations in Non-small Cell Lung Cancer
Hang Thuy Nguyen1, Thinh Van Hoang1, Diep Bui Ngoc Nguyen1, Thong Quang Pham1, Thang Thanh Phan11Department of Clinical Pathology, Cho Ray Hospital, Ho Chi Minh City, 700000, Viet Nam,
Objectives: This study aims to describe the characteristics of epidermal growth factor receptor (EGFR) mutations in correlation with clinical features of Vietnamese non-small cell lung cancer (NSCLC), and identify the predictive factor for the incidence of EGFR mutations. Methods: A total of 1.548 newly diagnosed NSCLC patients were selected for this retrospective study. EGFR mutations were detected in the tumor, lymph node tissue and pleural fluid by the pyrosequencing method. Results: EGFR mutations were detected in 623 patients (40.2%). Mutations were more frequent in the female patient (p<0.001), in adenocarcinoma (p=0.004), in pleural effusion sample (p=0.002), in the low-intermediate grade of the tumor (p<0.001), and in those with CK7-positive (p=0.001) and TTF1-positive result (p<0.001). Notably, the low grade of the tumor (p<0.001), TTF1-positive marker (p=0.001) and pleural fluid (p=0.002) were detected as independent factors for the higher incidence of EGFR mutations in multivariable analysis. In addition, CK7 marker played the role as an independent factor when TTF1 marker was not applied (p=0.011). Conclusion: EGFR mutations occur with high frequency in Vietnamese NSCLC patients. Histologic grade, TTF1 marker, and sample type are independent factors for the incidence of EGFR mutations. Keywords: EGFR mutations; NSCLC; histologic grade; pleural fluid; TTF1; CK7 markers
Cite This Article
Nguyen H, Hoang T, Nguyen D, Pham T, Phan T. Histologic Grade with Thyroid Transcription Factor 1 and Sample Type Serve as Independent Factors for the Incidence of EGFR Mutations in Non-small Cell Lung Cancer. EJMO. 2019; 3(2): 101-107
Corresponding Author: Thang Thanh Phan