Investigation of the Efficacy of Algan Hemostatic Agent in Liver Laceration Model in Rats
Ahmet Midi1, Ali Kumandas2, Husamettin Ekici3, Feyzanur Bayraktar4, Kubra Karapirli5, Siyami Karahan6, Mustafa Turk7, Hatice Emel Ozyurek81Department of Pathology, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey, 2Department of Surgery, Kirikkale University, Veterinary Faculty, Kirikkale, Turkey, 3Department of Pharmacology and Toxicology, Kirikkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 4Department of Medicine Faculty, Bahcesehir University, Faculty of Medicine, 3rd Grade Student, Istanbul, Turkey, 5Department of Medicine Faculty, Bahcesehir University, Faculty of Medicine, 4th Grade Student, Istanbul, Turkey, 6Department of Histology, Kirikkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 7Department of Bioengineering, Kirikkale University Faculty of Engineering, Kirikkale, Turkey, 8Department of Pediatrics and Section of Hematology, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey,
Objectives: Bleeding control is crucial in preventing negative consequences by reducing blood loss in surgical operations. The aim of this study is to evaluate the hemostatic effect of a new herbal hemostatic agent called Algan Hemostatic Agent (AHA) in an uncontrolled bleeding model made by liver laceration. Methods: In these study 5–7 weeks-old 64 rats were used. Rats were randomly divided into 8 groups each consisting of eight rats (4 groups heparinize and 4 groups non-heparinize). The experimental liver laceration was performed, and physiological serum impregnated gauze was applied to the control group for hemorrhage control, AHA liquid form impregnated gauze, AHA gel, and AHA powder form were applied to experimental groups, respectively. Results: The shortest bleeding time was found in the AHA powder group. The AHA powder form stopped the bleeding in the heparinize group for a mean of 4 s, the non-heparinized group for 2 s. This was followed by the gel group and the liquid group. The bleeding time was significantly shorter in the all AHA group compared to the control group. Conclusion: This study showed that AHA is a highly effective hemostatic agent in controlling bleeding compared to the control group. Keywords: Algan hemostatic agent, laceration, liver, rat
Cite This Article
Midi A, Kumandas A, Ekici H, Bayraktar F, Karapirli K, Karahan S, et al. Investigation of the Efficacy of Algan Hemostatic Agent in Liver Laceration Model in Rats. EJMO. 2019; 3(1): 37-42
Corresponding Author: Ahmet Midi