EJMO. 2019; 3(1): 37-42 | DOI: 10.14744/ejmo.2018.0008
Investigation of the Efficacy of Algan Hemostatic Agent in Liver Laceration Model in RatsAhmet Midi1
, Ali Kumandas2
, Husamettin Ekici3
, Feyzanur Bayraktar4
, Kubra Karapirli5
, Siyami Karahan6
, Mustafa Turk7
, Hatice Emel Ozyurek81
Department of Pathology, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey, 2
Department of Surgery, Kirikkale University, Veterinary Faculty, Kirikkale, Turkey, 3
Department of Pharmacology and Toxicology, Kirikkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 4
Department of Medicine Faculty, Bahcesehir University, Faculty of Medicine, 3rd Grade Student, Istanbul, Turkey, 5
Department of Medicine Faculty, Bahcesehir University, Faculty of Medicine, 4th Grade Student, Istanbul, Turkey, 6
Department of Histology, Kirikkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 7
Department of Bioengineering, Kirikkale University Faculty of Engineering, Kirikkale, Turkey, 8
Department of Pediatrics and Section of Hematology, Bahcesehir University, Faculty of Medicine, Istanbul, Turkey
Objectives: Bleeding control is crucial in preventing negative consequences by reducing blood loss in surgical operations.
The aim of this study is to evaluate the hemostatic effect of a new herbal hemostatic agent called Algan Hemostatic
Agent (AHA) in an uncontrolled bleeding model made by liver laceration.
Methods: In these study 5–7 weeks-old 64 rats were used. Rats were randomly divided into 8 groups each consisting
of eight rats (4 groups heparinize and 4 groups non-heparinize). The experimental liver laceration was performed, and
physiological serum impregnated gauze was applied to the control group for hemorrhage control, AHA liquid form
impregnated gauze, AHA gel, and AHA powder form were applied to experimental groups, respectively.
Results: The shortest bleeding time was found in the AHA powder group. The AHA powder form stopped the bleeding
in the heparinize group for a mean of 4 s, the non-heparinized group for 2 s. This was followed by the gel group and the
liquid group. The bleeding time was significantly shorter in the all AHA group compared to the control group.
Conclusion: This study showed that AHA is a highly effective hemostatic agent in controlling bleeding compared to
the control group.
Keywords: Algan hemostatic agent, laceration, liver, rat
Cite This Article
Midi A, Kumandas A, Ekici H, Bayraktar F, Karapirli K, Karahan S, Turk M, Ozyurek H. Investigation of the Efficacy of Algan Hemostatic Agent in Liver Laceration Model in Rats. EJMO. 2019; 3(1): 37-42
Corresponding Author: Midi A.
Full Text PDF