Objectives: The negative pressure wound therapy (NPWT) is a well?established advanced for treatment surgical site infections (SSI) such as wound suppuration, postoperative peritonitis or open abdominal. How-ever, the evidence base for use for complications in oncological surgery is very limited. Therefore, in this study assessed the 30-days results of NPWT in treatment SSI in oncological surgery. Methods: This is a retrospective cohort study which was performed in accordance with the STROBE protocol. The study included data of 446 patients who were underwent to radical cystectomy with uroderivation (RC) at the Oncourology department between January 2012 and December 2021. For next analysis 62 cases of SSI were allocated with com pletely data. These cases were separated into two groups: group A (n=36) of standard SSI's management and group B (n=26) of NPWT-dressing with VivanoTec® S042 device in constant negative pressure mode (85-110 mmHg). All calcula tions were performed with MS Excel and StatPlus:mac (2022). Results: SSIs were identified in 57 men (91.93%) and 5 cases in women (8.07%). The age, BMI in both groups did not differ. There was a statistically significant increase in CRP at the time of detection of SSI in group D - 233.72±139.67 mg/ ml (p=0.011). It was confirmed by the severity of the process according to the APACHE scale and correlation analysis (r=0.318, p=0.011). The mortality rate dur-ing hospitalization did not differ between groups. When conducting a one way analysis of variance in groups A and B, no convincing data were obtained on the effect of NPWT on mortality (F=2.68 p=0.106). Conclusion: The NPWT dressing does not negatively affect on incidence of postoperative mortality, intestinal fis-tulas or lateralization of wound edges. The method showed identical results in comparison with the standard method, de spite the inclusion cases with more severe inflammatory processes (90% of pa-tients with APACHEII scale > 20 points). Keywords: Radical cystectomy, surgical site infection, peritonitis, negative pressure wound dressing, open ab-dominal
Corresponding Author: Mariya Berkut Vladimirovna