EJMO. 2017; 1(1): 1-7 | DOI: 10.14744/ejmo.2017.22931

Frequency of Ras Mutations (Kras, Nras, Hras) in Human Solid Cancer

Hilmi Kodaz¹, Osman Kostek², Muhammet Bekir Hacioglu², Bulent Erdogan², Cagnur Elpen Kodaz³, Ilhan Hacibekiroglu⁴, Esma Turkmen², Sernaz Uzunoglu², Irfan Cicin^2
1Department of Medical Oncology, Acibadem Eskisehir Hospital, Eskisehir, Turkey, ²Department of Medical Oncology, Trakya University Faculty of Medicine, Edirne, Turkey, ³Department of Health, Acibadem Eskisehir Hospital, Eskisehir, Turkey, ⁴Department of Medical Oncology, Sakarya University Faculty of Medicine, Sakarya, Turkey,

RAS oncogene affects numerous cellular functions including growth, proliferation, apoptosis, migration, division and differentiation of the cells. It has 3 known isoforms as Harvey- RAS (HRAS), Kirsten - RAS (KRAS) and Neuroblastoma- RAS (NRAS). RAS has an intrinsic GTPase activity. It encodes proteins binding the guanine nucleotides. KRAS and HRAS were discovered in studies carried out on viruses leading to cancer. Retroviral oncogenes related to murine sarcoma virus genes (Kristen Rat Sarcoma Virus and Murine Sarcoma Virus) were discovered in 1982. These two oncogenes are similar to human KRAS. Approximately 30% of all human cancers have ras genes. Mutations in KRAS account for about 85% for all RAS mutations in human tumors, NRAS is about 11–15%, and HRAS is about 1%.

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Cite This Article

Kodaz H, Kostek O, Hacioglu M, Erdogan B, Elpen Kodaz C, Hacibekiroglu I, et al. Frequency of Ras Mutations (Kras, Nras, Hras) in Human Solid Cancer. EJMO. 2017; 1(1): 1-7

Corresponding Author: Hilmi Kodaz

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